Datura inoxia (thorn-apple, downy thorn-apple, Indian-apple, lovache,moonflower, sacred datura, nacazcul, toloatzin, tolguache or toloache) is a species in the family Solanaceae. Datura inoxia is an annual shrubby plant that typically reaches a height of 0.6 to 1.5 metres. Its stems and leaves are covered with short and soft grayish hairs, giving the whole plant a grayish appearance. All parts of the plant emit a foul odor similar to rancid peanut butter when crushed or bruised, although most people find the fragrance of the flowers to be quite pleasant when they bloom at night. The flowers are white, trumpet-shaped, 12–19 cm long. They first grow upright, and later incline downward. It flowers from early summer until late fall. The fruit is an egg-shaped spiny capsule, about 5 cm in diameter. It splits open when ripe, dispersing the seeds.

All parts of Datura plants contain dangerous levels of poison and may be fatal if ingested by humans and other animals, including livestock and pets. When cultivated, the plant is usually grown from seed, but its perennial rhizomes can be kept from freezing and planted in the spring of the following year. Datura inoxia, like other Datura species, contains the highly toxic alkaloids atropine, hyoscine, andhyoscyamine. Datura intoxication typically produces a complete inability to differentiate reality from fantasy, hyperthermia, tachycardia, bizarre, and possibly violent behavior that can last several days. Pronounced amnesia is another commonly reported effect. It has also been planted throughout the world as an ornamental plant for its attractive large leaves, large white flowers, and distinctive thorny fruit. Datura inoxia is closely related to Datura stramonium (see offer) differs in having smaller flowers and tooth-edged leaves.